反应详情

To a solution of compound 1 (1.83 g) in EtOAc (50 mL) was added acryloyl chloride (1.35 g, 1.5 eq.) and Na2CO3 (2.12 g, 2.0 eq.). The reaction mixture was stirred at r.t. overnight and triethylamine was added. After stirring for 20 min, the mixture was washed with H2O (20 mL), 1N HCl (2×20 mL) and sat. NaHCO3 (2×20 mL). The solvents were removed by evaporation under reduced pressure to give product 32 as white solid (one spot on TLC). Yield: 2.2 g, 92.8%.

1. stirringAfter stirring for 20 min
2. washthe mixture was washed with H2O (20 mL), 1N HCl (2×20 mL) and sat. NaHCO3 (2×20 mL)
3. customThe solvents were removed by evaporation under reduced pressure