5-Bromouracil → Dimethylformamide

HRID 1917099Notes

Reaction equation

HRID 1917099 reaction equation
Br[C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.Cl.[N:11]1([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]([F:28])([F:27])[F:26])=[O:18])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[F:28][C:25]([F:26])([F:27])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:17]([N:11]1[CH2:12][CH2:13][N:14]([C:2]2[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=2)[CH2:15][CH2:16]1)=[O:18].[CH3:12][N:11]([CH3:16])[CH:17]=[O:18]

Participants

4

Reactant 2

HCID 58025-BromouracilHCID 167337831-(2-Trifluoromethylbenzoyl)piperazine hydrochloride

Product 2

HCID 6228DimethylformamideYield 47%HCID 44621498HCID 44621498, compound

Procedure

The compound 6 (solid) is prepared from 5-bromo-1H-pyrimidine-2,4-dione and from the intermediate 6a according to the synthesis method 1 in dimethylformamide (yield: 47%).

Sources & evidence

ORD record
ord-939e765c7f64415ea75f42a13ddd84df
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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