反应详情

温度

0 °C

The compound 40 is prepared according to the synthesis method 2: 0.16 g (0.72 mmol) of derivative 12a is placed in 1 mL of dichloromethane in the presence of 0.15 mL (1.08 mmol) of NEt3 at 0° C. 0.2 g (0.72 mmol) of 2,5-bis-trifluoromethyl-benzoyl chloride is added. This mixture is stirred for 15 min at 0° C., and then for 1 h at room temperature. The medium is taken up with water and extracted with CH2Cl2. After drying on MgSO4, the organic phase is concentrated. The obtained residue is purified by flash chromatography on silica (CH2Cl2-AcOEt: 90-10). 0.24 g of white crystals are isolated (yield: 71%).

1. customaccording to the synthesis method 2
2. waitfor 1 h at room temperature
3. extractionextracted with CH2Cl2
4. customAfter drying on MgSO4
5. concentrationthe organic phase is concentrated
6. customThe obtained residue is purified by flash chromatography on silica (CH2Cl2-AcOEt: 90-10)