Ethylamine hydrochloride → HCID 59144142, compound

HRID 1917137Notes

Reaction equation

HRID 1917137 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH2:9][O:8][C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]1=2)=[O:4].C([O-])([O-])=O.[K+].[K+].Cl.[CH2:25]([NH2:27])[CH3:26]>C(#N)C>[CH2:25]([NH:27][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][O:8][C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]1=2)=[O:4])[CH3:26]

Participants

5

Reactant 3

HCID 11198Ethylamine hydrochlorideHCID 11430Potassium CarbonateHCID 14880548HCID 14880548, compound

Product 1

HCID 59144142HCID 59144142, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 2-chloro-1-(7-nitro-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone (9.9 g, 38.6 mmol) in anhydrous acetonitrile (250 mL) under positive argon pressure was treated with K2CO3 (42.7 g, 309 mmol) to give a yellow suspension. The mixture was cooled to 0° C. and treated with ethanamine hydrochloride (15.7 g, 193 mmol). The reaction was brought to room temperature and stirred for 2.5 hours. The mixture was then filtered through a pad of Celite, washed with CH2Cl2 (500 mL), and concentrated. The residue was subjected to flash chromatography on silica gel using EtOAc, followed by 2.5:97.5 (2M NH3 in MeOH):CH2Cl2 to give a yellow solid (7.73 g, 76%). 1H-NMR (DMSO-d6) δ 8.29 (d, J=9.0 Hz, 1H), 7.80 (dd, J=2.7, 9.3 Hz, 1H), 7.71 (d, J=2.7 Hz, 1H), 4.36 (t, J=4.2 Hz, 2H), 3.93 (t, J=4.8 Hz, 2H), 3.71 (s, 2H), 2.62 (q, J=7.2 Hz, 2H), 1.05 (t, J=7.2 Hz, 3H). ESI-MS (m/z, %): 266.1 (MH+, 100).

Workup

  1. customto give a yellow suspension
  2. customwas brought to room temperature
  3. filtrationThe mixture was then filtered through a pad of Celite
  4. washwashed with CH2Cl2 (500 mL)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5436cd368188423093c16af426026113
Source dataset
uspto-grants-2013_12
Patent number
US08618286B2

Reaction notes

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