Hydrochloric Acid → HCID 68487959, compound

HRID 1918463Notes

Reaction equation

HRID 1918463 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.[C:9]1([S:15][CH:16]=[CH:17][C:18](Cl)=[O:19])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl>C(#N)C>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:18](=[O:19])[CH:17]=[CH:16][S:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7813p-ToluidineHCID 713526793-(Phenylsulfanyl)prop-2-enoyl chloride

Product 1

HCID 68487959HCID 68487959, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

p-Toluidine (2.46 g) was dissolved to acetonitrile (20 ml), then acetonitrile (3 ml) solution of 3-(phenylthio)acryloyl chloride (2.0 g) was added dropwise thereto under ice-cooling. The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into 50 ml of ice-water, and adjusted to pH 4 with concentrated hydrochloric acid. The precipitated crystal was collected by filtration, washed with water and dried to obtain N-(4-methylphenyl)-3-(phenylthio)acrylamide (2.62 g) as light brown crystal.

Workup

  1. temperatureunder ice-cooling
  2. filtrationThe precipitated crystal was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7217aa027907497eba61ca1695a7bca5
Source dataset
uspto-grants-2013_12
Patent number
US08618329B2

Reaction notes

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