反应详情

温度

90 °C

A microwave vial equipped with a magnetic stirrer was charged with 3,5-dibromo-1-methylpyrazin-2(1H)-one (1.97 g, 7.4 mmol), 4-morpholinobenzenamine (1.97 g, 11.1 mmol), and isopropanol (25 mL). The system was evacuated and then refilled with N2. It was heated at 90° C. for 16 h. Then, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by flash column chromatography eluting with 5:1 petroleum ether/ethyl acetate to afford 122a (2.3 g, 85%). LCMS: [M+H]+ 365.

1. customA microwave vial equipped with a magnetic stirrer
2. customThe system was evacuated
3. additionrefilled with N2
4. temperatureThen, the mixture was cooled to room temperature
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by flash column chromatography
7. washeluting with 5:1 petroleum ether/ethyl acetate