Water → HCID 57500685, compound

HRID 1919672Notes

Reaction equation

HRID 1919672 reaction equation
Cl[C:2]1[C:11]2[CH:12]=[CH:13][N:14]=[CH:15][C:10]=2[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20].O>CN1C(=O)CCC1>[Cl:16][C:17]1[CH:18]=[C:19]([NH:20][C:2]2[C:11]3[CH:12]=[CH:13][N:14]=[CH:15][C:10]=3[C:9]3[CH:8]=[CH:7][N:6]=[CH:5][C:4]=3[N:3]=2)[CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 962WaterHCID 79323-ChloroanilineHCID 57500684HCID 57500684, compound

Product 1

HCID 57500685HCID 57500685, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
120 °C

Procedure

5-chloropyrido[4,3-c][1,7]naphthyridine (10 mg) was mixed in NMP (0.3 ml) with 3-chloroaniline (60 ul) and the mixture was heated at 120° C. for 10 min. Water was added and the resulting solid was filtered and dried. N-(3-chlorophenyl)pyrido[4,3-c][1,7]naphthyridin-5-amine was isolated as a solid (5 mg). LCMS (ES)>95% pure, m/z 307 [M+1]+.

Workup

  1. filtrationthe resulting solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-e340a6259ca541109f1e2b5425a2f606
Source dataset
uspto-grants-2012_05
Patent number
US08168651B2

Reaction notes

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