反应详情

5-Hydroxypent-2-yl acetate (58.5 mg), triphenylphosphine (131 mg) and ethyl azodicarboxylate (2.2 mol/L, 200 μL) were added to a mixed solution of 4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenol (69.3 mg, 200 μmol) in tetrahydrofuran (2 mL) at room temperature. After completion of the reaction, the solvent was evaporated, and the residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=5:1) to obtain 80.4 mg of the title compound (yield: 85%) as a colorless oil.

1. customAfter completion of the reaction
2. customthe solvent was evaporated
3. customthe residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=5:1)