Benzyl chloroformate → 2′-[[Cyclobutyl[(phenylmethoxy)carbonyl]amino]methyl]-6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-3-acetic acid

HRID 1919930Notes

Reaction equation

HRID 1919930 reaction equation
C[O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH:23]=O)[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.[CH:26]1([NH2:30])[CH2:29][CH2:28][CH2:27]1.Cl[C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33]>>[CH2:35]([O:34][C:32]([N:30]([CH2:23][C:14]1[CH:15]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:18][C:13]=1[C:7]1[C:8]([O:11][CH3:12])=[CH:9][CH:10]=[C:5]([CH2:4][C:3]([OH:25])=[O:2])[CH:6]=1)[CH:26]1[CH2:29][CH2:28][CH2:27]1)=[O:33])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 3

HCID 10387Benzyl chloroformateHCID 75645CyclobutylamineHCID 86633167(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 441596472′-[[Cyclobutyl[(phenylmethoxy)carbonyl]amino]methyl]-6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-3-acetic acid

Procedure

{2′-[(Benzyloxycarbonyl-cyclobutyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (Compound 1-34) was prepared by following the procedures of Example 1 and using the following starting materials: (2′-formyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester, cyclobutylamine, and benzyl chloroformate.

Sources & evidence

ORD record
ord-d968a864409a48ac84494271c1e6d644
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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