Tetrahydrofuran → 3-Cyclopentyl-1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide

HRID 191996Notes

Reaction equation

HRID 191996 reaction equation
[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[CH3:21][O:22][C:23](=[O:24])[C:25]1([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:26][N:27]([c:31]2[c:32]([CH3:38])[cH:33][cH:34][cH:35][c:36]2[CH3:37])[C:28](=[O:30])[CH2:29]1.[F:6][C:7]([c:8]1[cH:9][c:10]([NH2:11])[cH:12][c:13]([C:15]([F:16])([F:17])[F:18])[cH:14]1)([F:19])[F:20]>>[F:6][C:7]([c:8]1[cH:9][c:10]([NH:11][C:23](=[O:22])[C:25]2([CH:39]3[CH2:40][CH2:41][CH2:42][CH2:43]3)[CH2:26][N:27]([c:31]3[c:32]([CH3:38])[cH:33][cH:34][cH:35][c:36]3[CH3:37])[C:28](=[O:30])[CH2:29]2)[cH:12][c:13]([C:15]([F:16])([F:17])[F:18])[cH:14]1)([F:19])[F:20]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 582188033-Cyclopentyl-1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl esterHCID 178418339Butyllithium

Product 1

HCID 510339033-Cyclopentyl-1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide

Sources & evidence

ORD record
ord-23a5293ccded4ec2bd5d25f176e87c73
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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