Dichloromethane → HCID 86643443, compound

HRID 1920496Notes

Reaction equation

HRID 1920496 reaction equation
[CH2:1]([CH:5]1[CH2:11][C:10](=[O:12])[O:9][C:7](=[O:8])[CH2:6]1)[CH:2]([CH3:4])C.[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14].Cl[CH2:19]Cl>>[CH2:13]([N:15]([CH2:16][CH3:17])[C:10](=[O:12])[CH2:11][CH:5]([CH2:1][CH2:2][CH3:4])[CH:6]([CH3:19])[C:7]([OH:9])=[O:8])[CH3:14]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8021DiethylamineHCID 11480690Dihydro-4-(2-methylpropyl)-2H-pyran-2,6(3H)-dione

Product 1

HCID 86643443HCID 86643443, compound

Conditions

Temperature
25 °C

Procedure

To a solution of 3-isobutyl glutaric anhydride (5 grams) in dichloromethane (10 ml), added diethyl amine (4.3 grams) and stirred the reaction mixture for 12 hrs at 25° C. The reaction mixture was quenched with water (10 ml) and the pH of the reaction mixture adjusted to 1.0 using hydrochloric acid. The organic layer was separated and the aqueous layer was extracted with dichloromethane. The organic layers were combined and the solvent distilled off to provide the title compound as a residue.

Workup

  1. customThe reaction mixture was quenched with water (10 ml)
  2. customThe organic layer was separated
  3. extractionthe aqueous layer was extracted with dichloromethane
  4. distillationthe solvent distilled off

Sources & evidence

ORD record
ord-64293e850522494b927d7e6da5016348
Source dataset
uspto-grants-2012_05
Patent number
US08168828B2

Reaction notes

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