Hydrogen Bromide → HCID 67496128, compound

HRID 1920560Notes

Reaction equation

HRID 1920560 reaction equation
[Br-].C(OC([NH:9][CH:10]([CH3:37])[CH2:11][N+:12]12[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]1)[C@@H:14]([O:20][C:21](=[O:36])[C:22]([OH:35])([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:13]2)=O)(C)(C)C.Br.[ClH:39]>O1CCOCC1>[ClH:39].[Cl-:39].[NH2:9][CH:10]([CH3:37])[CH2:11][N+:12]12[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]1)[C@@H:14]([O:20][C:21](=[O:36])[C:22]([OH:35])([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:13]2

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 131729691HCID 131729691, compound

Product 1

HCID 67496128HCID 67496128, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

This compound is prepared analogously to (R)-1-((R/S)-2-Amino-ethyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide hydrobromide [Example 49ii] but by replacing (R)-1-(2-tert-butoxycarbonylamino-ethyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide [Example 49i] with (R)-1-((R/S)-2-tert-Butoxycarbonylamino-propyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide [Example 164] and hydrogen bromide solution in dioxane with hydrogen chloride solution in dioxane. The product is isolated on concentration of the reaction medium, without further purification.

Workup

  1. customThe product is isolated on concentration of the reaction medium, without further purification

Sources & evidence

ORD record
ord-c48b345c840040f282eba8f1d3a8d4ab
Source dataset
uspto-grants-2012_05
Patent number
US08168654B2

Reaction notes

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