HCID 67496327, compound → HCID 67496802, compound

HRID 1920564Notes

Reaction equation

HRID 1920564 reaction equation
[Br-:1].C([O:9][C:10]1[CH:45]=[CH:44][C:13]([C:14]([NH:16][CH2:17][CH2:18][N+:19]23[CH2:26][CH2:25][CH:22]([CH2:23][CH2:24]2)[C@@H:21]([O:27][C:28](=[O:43])[C:29]([OH:42])([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:20]3)=[O:15])=[CH:12][CH:11]=1)C1C=CC=CC=1>CN(C=O)C.[Pd]>[Br-:1].[OH:9][C:10]1[CH:11]=[CH:12][C:13]([C:14]([NH:16][CH2:17][CH2:18][N+:19]23[CH2:24][CH2:23][CH:22]([CH2:25][CH2:26]2)[C@@H:21]([O:27][C:28](=[O:43])[C:29]([OH:42])([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:20]3)=[O:15])=[CH:44][CH:45]=1

Participants

4

Reactant 1

HCID 67496327HCID 67496327, compound

Product 1

HCID 67496802HCID 67496802, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

To a solution of (R)-1-[2-(4-Benzyloxy-benzoylamino)-ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide (0.075 g, 0.11 mmol) in DMF (1 ml) under an argon atmosphere is added 10% Pd on carbon (40 mg) and the resulting solution hydrogenated for 3 hours. The catalyst is then removed by filtration and concentration in vacuo yields the title compound.

Workup

  1. customThe catalyst is then removed by filtration and concentration in vacuo

Sources & evidence

ORD record
ord-4f90aa2f6ede465c86aa26170362b57a
Source dataset
uspto-grants-2012_05
Patent number
US08168654B2

Reaction notes

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