Sodium hydride → Diallyl [4-(tert-butoxycarbonyl)benzyl]malonate

HRID 1920588Notes

Reaction equation

HRID 1920588 reaction equation
[H-].[Na+].[C:3]([O:12][CH2:13][CH:14]=[CH2:15])(=[O:11])[CH2:4][C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6].Cl[CH2:17][C:18]1[CH:30]=[CH:29][C:21]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[CH:20][CH:19]=1.[Cl-].[NH4+]>O1CCOCC1.C1COCC1.O>[C:25]([O:24][C:22]([C:21]1[CH:29]=[CH:30][C:18]([CH2:17][CH:4]([C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[C:3]([O:12][CH2:13][CH:14]=[CH2:15])=[O:11])=[CH:19][CH:20]=1)=[O:23])([CH3:28])([CH3:26])[CH3:27]

Participants

8

Reactant 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 228227Diallyl malonateHCID 18959012tert-Butyl 4-(chloromethyl)benzoate

Product 1

HCID 57965757Diallyl [4-(tert-butoxycarbonyl)benzyl]malonate

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 312751,4-DioxaneSolvent2×

Procedure

At 0° C., 6.29 g (0.16 mol) of sodium hydride (careful: evolution of hydrogen) are added a little at a time to a solution of 48.24 g (0.26 mol) of diallyl malonate in 100 ml of dioxane and 40 ml of THF. After warming to room temperature, the mixture is stirred at 40° C. for 1 hour. At 40° C., 29.69 g (0.13 mol) of tert-butyl 4-chloromethylbenzoate, dissolved in 100 ml of dioxane and 40 ml of THF, are slowly added dropwise, and the reaction solution is then stirred at a bath temperature of 110° C. overnight. After cooling to room temperature, 40 ml of saturated ammonium chloride solution and 100 ml of water are added carefully to the reaction mixture. The mixture is then extracted three times with ethyl acetate, and the combined organic phases are washed with saturated sodium chloride solution and dried over sodium sulfate. After filtration, the solvent is evaporated to dryness under reduced pressure. The crude product obtained is purified by flash chromatography on 2 kg of silica gel (mobile phase: petroleum ether/ethyl acetate 20:1). This gives 30.4 g (81 mmol, 62% of theory) of a colorless solid.

Workup

  1. stirringthe reaction solution is then stirred at a bath temperature of 110° C. overnight
  2. temperatureAfter cooling to room temperature
  3. extractionThe mixture is then extracted three times with ethyl acetate
  4. washthe combined organic phases are washed with saturated sodium chloride solution
  5. dry with materialdried over sodium sulfate
  6. filtrationAfter filtration
  7. customthe solvent is evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c665611eaac049a29986e20b8d602f48
Source dataset
uspto-grants-2012_05
Patent number
US08168821B2

Reaction notes

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