反应详情

10 g (66.6 mmol) 2,6-diaminopurine were suspended under argon in 300 ml DMF and 21.6 g (156.5 mmol) potassium carbonate and 24 ml 1-bromo-2-chloroethane were added. The mixture was stirred for 64 hours at room temperature. The light yellow suspension was filtered and the solids were washed with 30 ml DMF and subsequently triturated with 100 ml water for 30 minutes. The mixture was filtered and the solids were washed with 50 ml water and dried in vacuo to give 10.15 g (72%) of the desired product as a white solid.

1. filtrationThe light yellow suspension was filtered
2. washthe solids were washed with 30 ml DMF
3. customsubsequently triturated with 100 ml water for 30 minutes
4. filtrationThe mixture was filtered
5. washthe solids were washed with 50 ml water
6. customdried in vacuo