Trifluoroacetic acid → HCID 16662203, compound

HRID 1920950Notes

Reaction equation

HRID 1920950 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH2:16][CH:9]1[CH2:10][NH:11][CH2:12]2)=O)(C)(C)C.Cl[C:18]1[N:19]=[N:20][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:22][CH:23]=1.C(O)(C(F)(F)F)=O>>[C:24]1([C:21]2[N:20]=[N:19][C:18]([N:11]3[CH2:12][CH:13]4[NH:8][CH:9]([CH2:16][CH2:15][CH2:14]4)[CH2:10]3)=[CH:23][CH:22]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 885153-Chloro-6-phenylpyridazineHCID 545955399-Boc-3,9-diaza-bicyclo[3.3.1]nonane

Product 1

HCID 16662203HCID 16662203, compound

Procedure

Was prepared according to reaction-conditions of Method A from 9-tert-butoxycarbonyl-3,9-diazabicyclo[3.3.1]nonane and 3-chloro-6-phenylpyridazine at 130° C. for 3 days, followed by treatment with TFA. Workup procedure was done according to Method A. LC-ESI-HRMS of [M+H]+ shows 281.1761 Da. Calc. 281.176621 Da, dev. −1.9 ppm.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-6cc36df180d34ede8071dd02eaf4ed03
Source dataset
uspto-grants-2012_05
Patent number
US08173658B2

Reaction notes

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