Dichloromethane → HCID 18449380, compound

HRID 1921192Notes

Reaction equation

HRID 1921192 reaction equation
[CH3:1][S:2]([C:4]1[N:5]=[C:6]([N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[C:10]2=[O:26])[S:7][CH:8]=1)=[O:3].C(Cl)Cl>C(C(O)=O)(F)(F)F>[CH3:1][S:2]([C:4]1[N:5]=[C:6]([N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]([CH2:18][C:19]([OH:21])=[O:20])[C:10]2=[O:26])[S:7][CH:8]=1)=[O:3]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 86607785HCID 86607785, compound

Product 1

HCID 18449380HCID 18449380, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

(±)-tert-Butyl {3-[4-(methylsulfinyl)-1,3-thiazol-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetate from Step D (100 mg, 0.254 mmol) was dissolved in CF3CO2H (3 mL) and CH2Cl2 (3 mL) and the mixture was stirred at ambient temperature for 3 h, then concentrated in vacuo to give the title compound. MS: m/z=338 (M+1).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e1df370f8b0a45b6b58caf8c33af93bb
Source dataset
uspto-grants-2012_05
Patent number
US08173655B2

Reaction notes

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