Piperazine → HCID 67492426, compound

HRID 1921433Notes

Reaction equation

HRID 1921433 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[ClH:19].[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 67492426HCID 67492426, compoundYield 73.3%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with piperazine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (73.3% yield). LC/MS: RT 2.07 min; m/e 368 (M+H); 1H NMR (δ, ppm): 11.8 (1H, br s), 9.5 (1H, s), 7.65 (1H, d); 7.35 (1H, s); 7.3 (1H, d), 3.2 (8H, m), 2.4 (2H, q), 2.36 (3H, s), 1.1 (3H, t).

Sources & evidence

ORD record
ord-75347011872c42ccbdbebba2cd20d6cd
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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