Hydrochloric Acid → HCID 178484813, compound

HRID 1922014Notes

Reaction equation

HRID 1922014 reaction equation
CC(O[C:6]([N:8](C)[C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1)=O)(C)C.Cl>O1CCOCC1>[CH3:6][NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486046HCID 178486046, compound

Product 1

HCID 178484813HCID 178484813, compoundYield 51.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of cis-4-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]cyclohexane carboxylic acid (2.5 g, 16 mmol, 1.0 equiv) and 1 M HCl in dioxane (15 mL) was heated to reflux for 4 h. The solvent was removed under reduced pressure to afford 1.3 g of the title compound. This material was used without purification.

Workup

  1. temperatureto reflux for 4 h
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-e298bc940c2f4281878aab7fed4d8370
Source dataset
uspto-grants-2012_05
Patent number
US08173805B2

Reaction notes

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