反应详情

Methanesulfonic acid 2-(3-nitro-phenyl)-ethyl ester was dissolved in piperidine (20 eq) and THF and stirred at 60° C. for one hour. The solvent was removed. The crude product was diluted with ethyl acetate, washed three times with water, dried with anhydrous sodium sulfate, filtered and concentrated. The product was clean enough to carry forward without purification. 44% yield. MH+=235.1.

1. customThe solvent was removed
2. additionThe crude product was diluted with ethyl acetate
3. washwashed three times with water
4. dry with materialdried with anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customto carry forward without purification