Tetrahydrofuran → 2-(3-Chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-(bicyclopropyl-1-ylcarbamoyl)-4-cyano-6-methyl-phenyl]-amide
Reaction equation
[C:1]1([CH:4]2[CH2:5][CH2:6]2)([NH:7][C:8](=[O:9])[c:10]2[c:11]([NH:18][C:19](=[O:20])[c:21]3[n:22](-[c:30]4[n:31][cH:32][cH:33][cH:34][c:35]4[Cl:36])[n:23][c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]3)[c:12]([CH3:17])[cH:13][c:14]([I:16])[cH:15]2)[CH2:2][CH2:3]1.[Cu:37][C:38]#[N:39].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1.[Pd:45].[c:103]1([P:104]([c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[cH:117][cH:118][cH:119][cH:120][cH:121]1.[c:46]1([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[cH:60][cH:61][cH:62][cH:63][cH:64]1.[c:65]1([P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[cH:79][cH:80][cH:81][cH:82][cH:83]1.[c:84]1([P:85]([c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[cH:98][cH:99][cH:100][cH:101][cH:102]1>>[C:1]1([CH:4]2[CH2:5][CH2:6]2)([NH:7][C:8](=[O:9])[c:10]2[c:11]([NH:18][C:19](=[O:20])[c:21]3[n:22](-[c:30]4[n:31][cH:32][cH:33][cH:34][c:35]4[Cl:36])[n:23][c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]3)[c:12]([CH3:17])[cH:13][c:14]([C:38]#[N:39])[cH:15]2)[CH2:2][CH2:3]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-894621129efc44b392ce7462e3769e0f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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