反应详情

To a stirred solution of 2-methyl-thiazole-5-carboxylic acid (100 mg, 0.7 mmol) in THF (5 mL) at −72° C. and under argon was added LDA (0.7 mL of a 2M solution in THF, 1.40 mmol) dropwise. After 1.5 h a solution of 4-chloromethyl-5-methyl-3-phenyl-isoxazole (145 mg, 0.7 mmol) in THF (5 mL) was added dropwise. After 1 h the reaction mixture was quenched with HCl (1N, 10 mL) then warmed to room temperature and extracted with ethyl acetate. The combined extracts were dried, filtered and concentrated then triturated with diisopropyl ether to give the title compound (135 mg, 61%) as a light brown solid which was used directly in the next reaction.

1. customAfter 1 h the reaction mixture was quenched with HCl (1N, 10 mL)
2. extractionextracted with ethyl acetate
3. customThe combined extracts were dried
4. filtrationfiltered
5. concentrationconcentrated
6. customthen triturated with diisopropyl ether