反应详情

To a suspension of 4-methyl-2-[2-(3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid methyl ester (647 mg, 2.0 mmol) in THF (6.5 mL) was added a solution of lithium hydroxide monohydrate (165 mg, 3.9 mmol) in water (6.5 mL) followed by methanol (4 mL) and the resulting mixture stirred at room temperature for 4 h. The mixture was then evaporated to half volume and then acidified to pH 4 with HCl (1N) and cooled to 0° C. for 30 min. A solid precipitated and was filtered off and dried to afford the title compound (578 mg, 93%) which was obtained as a light brown solid. MS: m/e=314.1 [M−H]−.

1. customThe mixture was then evaporated to half volume
2. temperaturecooled to 0° C. for 30 min
3. customA solid precipitated
4. filtrationwas filtered off
5. customdried