4-Aminotetrahydropyran → HCID 49782490, compound

HRID 1923513Notes

Reaction equation

HRID 1923513 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][CH2:14][C:15]1[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=1.[NH2:23][CH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[O:27]1[CH2:28][CH2:29][CH:24]([NH:23][C:20]([C:17]2[S:16][C:15]([CH2:14][CH2:13][C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:19][CH:18]=2)=[O:22])[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 66643592HCID 66643592, compound

Product 1

HCID 49782490HCID 49782490, compoundYield 46%

Procedure

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (77 mg, 0.24 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (45 mg, 46%) which was obtained as a white solid MS: m/e=399.1 [M+H]+.

Sources & evidence

ORD record
ord-43947c243f164505b513467f0eb0e82d
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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