Triethylamine → HCID 57477196, compound

HRID 1924009Notes

Reaction equation

HRID 1924009 reaction equation
Cl.[N:2]1[N:3]=[CH:4][N:5]2[CH2:10][CH2:9][NH:8][CH2:7][C:6]=12.C[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15].[CH3:18]C(OC(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[N:13]1([CH2:12][C:4]2[N:5]3[CH2:10][CH2:9][NH:8][CH2:7][C:6]3=[N:2][N:3]=2)[CH2:16][CH2:17][CH2:18][CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 90495Di-tert-butyl dicarbonateHCID 17998717HCID 17998717, compound

Product 1

HCID 57477196HCID 57477196, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (1.0 g, 6.23 mmol) in CH2Cl2 (25 mL) were added Et3N (2.17 mL, 15.57 mmol) and Boc2O (1.52 mL, 6.54 mmol) and the reaction was stirred at room temperature overnight. The mixture was extracted with aqueous 0.25 M KHSO4 (50 mL). The organic layer was dried (Na2SO4) and evaporated to dryness to afford compound A48-1 (1.29 g, 92%).

Workup

  1. extractionThe mixture was extracted with aqueous 0.25 M KHSO4 (50 mL)
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. customevaporated to dryness
  4. customto afford compound A48-1 (1.29 g, 92%)

Sources & evidence

ORD record
ord-7020123a39564a63b076da07d7ae0e00
Source dataset
uspto-grants-2012_05
Patent number
US08178535B2

Reaction notes

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