Hydrochloric Acid → HCID 86635050, compound

HRID 1924364Notes

Reaction equation

HRID 1924364 reaction equation
[CH:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[C:10]2[O:13][C@H:14]2[CH2:18][N:17](C(OC(C)(C)C)=O)[C@H:16]([C:26]([O:28][CH3:29])=[O:27])[CH2:15]2)=[CH:5][CH:4]=1)=[CH2:2].[ClH:30]>O1CCOCC1>[Cl-:30].[CH3:29][O:28][C:26]([C@@H:16]1[CH2:15][C@@H:14]([O:13][C:10]2[C:11]3[C:6](=[CH:5][CH:4]=[C:3]([CH:1]=[CH2:2])[CH:12]=3)[CH:7]=[CH:8][N:9]=2)[CH2:18][NH2+:17]1)=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58005118HCID 58005118, compound

Product 1

HCID 86635050HCID 86635050, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Carbamate from Step 2 was dissolved in a 4.0 M HCl solution in dioxane. The resulting mixture was stirred at RT for 0.5 h, during which time the product precipitated. The title compound was filtered off and washed with hexane/EtOAc 1/1 v/v. MS (ES+) C17H18N2O3 requires 298. Found: 299 (M+H+).

Workup

  1. customprecipitated
  2. filtrationThe title compound was filtered off
  3. washwashed with hexane/EtOAc 1/1 v/v

Sources & evidence

ORD record
ord-8c9af6f6062145a486a7b1057b343477
Source dataset
uspto-grants-2012_05
Patent number
US08178520B2

Reaction notes

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