HCID 67521026, compound → HCID 67521558, compound

HRID 1924423Notes

Reaction equation

HRID 1924423 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[N:12]([NH:23][C:24](=[O:34])[CH2:25][C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[C:28]([F:33])[CH:27]=1)[C:11]2=[O:35])(C)(C)C>Cl.C(O)(=O)C>[NH2:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[N:12]([NH:23][C:24](=[O:34])[CH2:25][C:26]1[CH:27]=[C:28]([F:33])[CH:29]=[C:30]([F:32])[CH:31]=1)[C:11]2=[O:35]

Participants

4

Reactant 1

HCID 67521026HCID 67521026, compound

Product 1

HCID 67521558HCID 67521558, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

{2-Diethylamino-3-[2-(3,5-difluoro-phenyl)-acetylamino]-4-oxo-3,4-dihydro-quinazolin-6-yl}-carbamic acid tert-butyl ester was dissolved in 1 M HCl in acetic acid. The mixture was stirred at RT for 1 h. The mixture was evaporated to near dryness, followed by addition of diethyl ether. The formed precipitate was collected by filtration, washed with diethyl ether and dried to give the title compound as a hydrochloride salt (0.40 g, 77%).

Workup

  1. customThe mixture was evaporated
  2. additionfollowed by addition of diethyl ether
  3. filtrationThe formed precipitate was collected by filtration
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-58fbdf0d52cc4c6e8c06d59dd471cc4e
Source dataset
uspto-grants-2012_05
Patent number
US08178544B2

Reaction notes

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