Hydrochloric Acid → 1-Phenyl-3-(2-o-tolyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

HRID 1924485Notes

Reaction equation

HRID 1924485 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[C:21]1([CH3:29])[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[NH:27]N.Cl>>[C:14]1([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:27]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[CH3:29])[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68256o-TolylhydrazineHCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

Product 1

HCID 462191921-Phenyl-3-(2-o-tolyl-2H-pyrazol-3-yl)-1H-pyridazin-4-oneYield 55%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and o-tolylhydrazine×HCl according to the method described for Example 1 in 55% yield. MS: M=329.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-9dc8f760076147159d08dedf0c1403e4
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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