Hydrochloric Acid → 3-[2-(2,5-Dimethyl-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-one

HRID 1924492Notes

Reaction equation

HRID 1924492 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:23]=1[NH:29]N.Cl>>[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:23]=1[N:29]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 853149(2,5-Dimethylphenyl)hydrazineHCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

Product 1

HCID 462194503-[2-(2,5-Dimethyl-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-oneYield 74%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and 2,5-dimethyl-phenylhydrazine×HCl according to the method described for Example 1 in 74% yield. MS: M=343.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-6b15fd9d320d422ab975493b743f5307
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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