Methyl iodide → HCID 59370073, compound

HRID 1924760Notes

Reaction equation

HRID 1924760 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[C:18](=[O:19])[CH:17]=[CH:16][N:15]([C:20]3[CH:21]=[C:22]([NH:26][C:27](=[O:29])[CH3:28])[CH:23]=[CH:24][CH:25]=3)[N:14]=2)=[CH:11][CH:10]=[N:9]1.[CH3:30]I.[H-].[Na+]>CN(C=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[C:18](=[O:19])[CH:17]=[CH:16][N:15]([C:20]3[CH:21]=[C:22]([N:26]([CH3:30])[C:27](=[O:29])[CH3:28])[CH:23]=[CH:24][CH:25]=3)[N:14]=2)=[CH:11][CH:10]=[N:9]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 46218709HCID 46218709, compound

Product 1

HCID 59370073HCID 59370073, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product was obtained starting from N-(3-{3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-4-oxo-4H-pyridazin-1-yl}-phenyl)-acetamide (example 292) and methyl iodide in presence of sodium hydride in DMF at room temperature over night. MS: M=404.4 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-a116b4f779014d01930a891c38db7b33
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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