反应详情

To a solution of 2-ethyl-6-methyl-isonicotinic acid (0.53 g, 3.2 mmol), hydrazinecarboxylic acid tert.-butyl ester (0.43 g, 3.2 mmol) and DIPEA (0.85 mL) in DMF (10 mL) is added TBTU (1.23 g, 3.8 mmol). The mixture is stirred at rt for 3 h. The mixture is diluted with 1M aq. NaOH (50 mL) and extracted with Et2O-EA (1:1, 3×50 mL). The organic extracts are dried (Na2SO4), filtered and evaporated to give crude N′-(2-ethyl-6-methyl-pyridine-4-carbonyl)-hydrazinecarboxylic acid tert-butyl ester.

1. extractionextracted with Et2O-EA (1:1, 3×50 mL)
2. dry with materialThe organic extracts are dried (Na2SO4)
3. filtrationfiltered
4. customevaporated