反应详情

5,8-Dibromo-3-methylimidazo[1,2-a]pyrazine (270 mg, 0.93 mmol) and 4-morpholinoaniline (200 mg, 1.1 mmol) are combined in nBuOH (10 mL) and DIPEA (240 μL, 1.4 mmol) is added. The mixture is heated at reflux for 10 h, cooled and the solvent removed under reduced pressure. The residue is purified by silica chromatography, eluting with 12%-100% EtOAc in cyclohexane, to afford the title compound as a red-brown solid (190 mg).

1. temperatureThe mixture is heated
2. temperatureat reflux for 10 h
3. temperaturecooled
4. customthe solvent removed under reduced pressure
5. customThe residue is purified by silica chromatography
6. washeluting with 12%-100% EtOAc in cyclohexane