Hydrochloric Acid → HCID 135995200, compound

HRID 1925019Notes

Reaction equation

HRID 1925019 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)[S:5][C:6]=1[CH3:7].Cl>O1CCOCC1>[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)[S:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59448347HCID 59448347, compound

Product 1

HCID 135995200HCID 135995200, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(5-(4,5-dimethyl-1,3-thiazol-2-yl)-2,4-bis(methyloxy)pyrimidine) (Prep14, 118 mg, 0.470 mmol) in HCl (5.87 ml, 23.48 mmol) 4M in dioxane was stirred in a closed tube at 90° C. for 1.5 hour. Then the mixture was cooled to rt and the solvent evaporated under vacuum to afford the title compound as a pale grey solid (153 mg)

Workup

  1. customthe solvent evaporated under vacuum

Sources & evidence

ORD record
ord-5d8f4f088ea94406982bd822478c6c80
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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