Hydrochloric Acid → HCID 67519674, compound

HRID 1925029Notes

Reaction equation

HRID 1925029 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[CH:5][N:4]=1.[ClH:16]>O1CCOCC1>[ClH:16].[S:12]1[CH:13]=[CH:14][N:15]=[C:11]1[C:6]1[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59448375HCID 59448375, compound

Product 1

HCID 67519674HCID 67519674, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2,4-bis(methyloxy)-5-(1,3-thiazol-2-yl)pyrimidine (Prep25, 294 mg, 1.225 mmol) was suspended in 4M HCl solution in 1,4-dioxane (25 ml) to give a white suspension. After 1 h at 90° C., the solvent was evaporated. 306.8 mg of the title compound were isolated as a white solid.

Workup

  1. customto give a white suspension
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-4691cde53b2d466da4147012d47aac93
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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