Hydrochloric Acid → HCID 67519603, compound

HRID 1925044Notes

Reaction equation

HRID 1925044 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[CH:5][C:4]([CH3:34])=[N:3]1.[ClH:35]>C(OCC)C>[ClH:35].[CH3:1][N:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[CH:5][C:4]([CH3:34])=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25252689HCID 25252689, compound

Product 1

HCID 67519603HCID 67519603, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5-(1,3-dimethyl-1H-pyrazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E3, 90 mg, 0.177 mmol) was dissolved in diethyl ether (2 ml) and HCl 1M in diethylether (0.177 mmol, 0.177 ml) was added dropwise. The white solid obtained was triturated in Et2O (2×4 ml) to give, after filtration, the title compound (50 mg, 0.078 mmol).

Workup

  1. customThe white solid obtained
  2. customwas triturated in Et2O (2×4 ml)
  3. customto give
  4. filtrationafter filtration

Sources & evidence

ORD record
ord-b96b92a5f39e4ca0996654cc9a61fb6c
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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