Hydrochloric Acid → HCID 67519639, compound

HRID 1925045Notes

Reaction equation

HRID 1925045 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[N:4][N:3]=1.[ClH:34]>C(OCC)C>[ClH:34].[ClH:34].[CH3:1][C:2]1[S:6][C:5]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25252822HCID 25252822, compound

Product 1

HCID 67519639HCID 67519639, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5-(5-methyl-1,3,4-thiadiazol-2-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E5, 7 mg, 0.015 mmol) was dissolved in diethyl ether (1 ml) and hydrochloric acid 1M in diethylether (0.030 ml, 0.030 mmol) was added. The solid obtained was triturated in diethylether (2×1 mL) giving the title compound as a white solid (8.8 mg, 0.014 mmol).

Workup

  1. customThe solid obtained
  2. customwas triturated in diethylether (2×1 mL)

Sources & evidence

ORD record
ord-c94880fc26374453922584fa3d2349f4
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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