Hydrochloric Acid → HCID 67519722, compound

HRID 1925047Notes

Reaction equation

HRID 1925047 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[CH:13]=2)[S:5][C:6]=1[CH3:7].[ClH:35]>C(OCC)C>[ClH:35].[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:32])[F:31])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[CH:13]=2)[S:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25252823HCID 25252823, compound

Product 1

HCID 67519722HCID 67519722, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E 7, 3 mg, 6.12 μmol) was suspended in Diethyl ether (0.5 ml). 1M Hydrochloric acid (7.34 μl, 7.34 μmol) in Et2O was added and the resulting solid was triturated with Et2O (3×0.3 mL) to afford the title compound as a yellowish solid (2.9, mg, 77% yield)

Workup

  1. customthe resulting solid was triturated with Et2O (3×0.3 mL)

Sources & evidence

ORD record
ord-53ab4142d80e4078a206f90d177d370b
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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