Hydrochloric Acid → HCID 67519619, compound

HRID 1925049Notes

Reaction equation

HRID 1925049 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][C@H:20]3[C@:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)([CH2:19]3)[CH2:17]2)[CH:12]=1.[ClH:34]>C(OCC)C>[ClH:34].[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][C@H:20]3[C@:18]([C:22]4[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=4)([CH2:19]3)[CH2:17]2)[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25252825HCID 25252825, compound

Product 1

HCID 67519619HCID 67519619, compoundYield 91.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5-(1-methyl-1H-pyrrol-2-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (18.1 mg, 0.039 mmol) was suspended in Diethyl ether (1 ml) and Hydrochloric acid (0.047 ml, 0.047 mmol) 1M in Et2O was added. A suspension was formed that was dried (vacuo). The white solid formed was triturated with Et2O (3×0.3 mL) to afford the title compound as a white solid (17.6 mg)

Workup

  1. customA suspension was formed
  2. customthat was dried (vacuo)
  3. customThe white solid formed
  4. customwas triturated with Et2O (3×0.3 mL)

Sources & evidence

ORD record
ord-14e780b175454910882989f81dc6f60c
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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