Hydrochloric Acid → 1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 1925053Notes

Reaction equation

HRID 1925053 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:5][CH:4]=1.[ClH:37]>C(OCC)C>[ClH:37].[ClH:37].[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[CH:5][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 252531381-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 866443941-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione (E20, 10.3 mg, 0.020 mmol) was dissolved in Diethyl ether (2 ml). 1M solution of HCl in Diethyl ether (0.044 ml, 0.044 mmol) was added. The solvent was evaporated to obtain 11.6 mg of the title compound as a yellow powder.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-250f9fc8a58c45ffaffca7a4f1d89103
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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