Hydrochloric Acid → HCID 86644397, compound

HRID 1925059Notes

Reaction equation

HRID 1925059 reaction equation
[F:1][C:2]([F:40])([F:39])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[C:32]5[CH2:31][CH2:30][CH2:29][CH2:28][C:27]=5[C:26]([C:33]([F:36])([F:35])[F:34])=[N:25]4)[C:21](=[O:37])[NH:20][C:19]2=[O:38])[CH2:10]3)=[CH:5][CH:4]=1.[ClH:41]>C(OCC)C>[ClH:41].[ClH:41].[F:40][C:2]([F:1])([F:39])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[C:32]5[CH2:31][CH2:30][CH2:29][CH2:28][C:27]=5[C:26]([C:33]([F:36])([F:35])[F:34])=[N:25]4)[C:21](=[O:37])[NH:20][C:19]2=[O:38])[CH2:10]3)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25253141HCID 25253141, compound

Product 1

HCID 86644397HCID 86644397, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-2,4(1H,3H)-pyrimidinedione (E26, 9.4 mg, 0.014 mmol) was dissolved and sonicated in Diethyl ether (1 ml) to give a colorless solution. 1.0 M solution of HCl in Diethyl ether (0.035 ml, 0.035 mmol) was added at room temperature. After 3 min and the solvent evaporated in vacuo. Obtained 9.7 mg of the title compound as a white powder.

Workup

  1. customto give a colorless solution
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-47942eb9385f43dea97f68d0c548d665
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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