Hydrochloric Acid → HCID 67519771, compound

HRID 1925063Notes

Reaction equation

HRID 1925063 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[CH:6]=1.[ClH:34]>C(OCC)C>[ClH:34].[ClH:34].[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25253293HCID 25253293, compound

Product 1

HCID 67519771HCID 67519771, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5-(4-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E31, 4.8 mg, 9.92 μmol) was dissolved and sonicated in Diethyl ether (1 ml) to give a colorless solution. 1.0 M solution of HCl in Diethyl ether (0.025 ml, 0.025 mmol) was added at room temperature. After 3 min the solvent was evaporated to obtain 5.3 mg of the title compound as a white powder.

Workup

  1. customto give a colorless solution
  2. customAfter 3 min the solvent was evaporated

Sources & evidence

ORD record
ord-8353a40e130741f498a5a760d3b3ad98
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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