Hydrochloric Acid → HCID 67519686, compound

HRID 1925066Notes

Reaction equation

HRID 1925066 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:9](=[O:35])[NH:10][C:11](=[O:34])[N:12]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=5)([CH2:21]4)[CH2:19]3)[CH:13]=2)=[C:5]([CH3:7])[N:6]=1.[ClH:36].CCOCC>C(Cl)Cl>[ClH:36].[ClH:36].[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:9](=[O:35])[NH:10][C:11](=[O:34])[N:12]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:25]=[CH:26][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:28][CH:29]=5)([CH2:21]4)[CH2:19]3)[CH:13]=2)=[C:5]([CH3:7])[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 25253295HCID 25253295, compound

Product 1

HCID 67519686HCID 67519686, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-(2,4-dimethyl-1,3-thiazol-5-yl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione (E35) was dissolved in DCM and treated with HCl 1N solution in Et2O (2.2 eq) to form the title compound (31 mg, 0.054 mmol) as a white powder.

Sources & evidence

ORD record
ord-261e3fea551c47618702cabde6b405e2
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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