反应详情

A solution of compound 10C (1.00 g, 4.46 mmol) and 4-bromo-2-fluoro-1-nitro-benzene (10D) (0.97 g, 4.40 mmol) in DMF (50 mL) with DIEA (1.30 g, 10 mmol) was stirred at 65° C. for two hours. The reaction was poured into ice/water and the solid precipitate was collected by filtration, washed with water and dried in vacuum over P2O5 overnight to give 1.5 g of desired product (10E). ESI-MS:m/z 342.9 (M+H)+.

1. filtrationthe solid precipitate was collected by filtration
2. washwashed with water
3. dry with materialdried in vacuum over P2O5 overnight