Hydrazine hydrate (1:1) → 2-(6-Hydrazinylpyridin-3-yl)propan-2-ol

HRID 1925129Notes

Reaction equation

HRID 1925129 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.O.[NH2:13][NH2:14]>>[NH:13]([C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1)[NH2:14]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 125621182-(6-Chloropyridin-3-yl)propan-2-ol

Product 1

HCID 552817922-(6-Hydrazinylpyridin-3-yl)propan-2-ol

Conditions

Temperature
110 °C

Procedure

A mixture of 2-(6-chloropyridin-3-yl)propan-2-ol (975 mg, 5.68 mmol), and hydrazine hydrate (5512 μl, 114 mmol) was heated in a microwave on high absorbance for 10 hr at 110° C. The mixture was cooled to room temperature and the hydrazine was removed via rotary evaporation. The resulting yellow residue was used without further work-up.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. customthe hydrazine was removed via rotary evaporation

Sources & evidence

ORD record
ord-27ccae116e6240efa30b94b759b11845
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

Loading…