反应详情

To a mixture of 6-chloro-3-fluoro-2-methylpyridine (4.7 g, 32.3 mmol) in isopropanol (100 mL) was added hydrazine hydrate (5 g, 100 mmol). After the mixture was refluxed for 5 hrs, additional hydrazine hydrate (5 g, 100 mmol) was added, and the reaction was refluxed for 3 days. The mixture was then concentrated to dryness and stored under high vacuum overnight. This material was used without further purification.

1. temperatureAfter the mixture was refluxed for 5 hrs
2. temperaturethe reaction was refluxed for 3 days
3. concentrationThe mixture was then concentrated to dryness
4. customstored under high vacuum overnight
5. customThis material was used without further purification