Phosphorus oxychloride → HCID 67520363, compound

HRID 1925312Notes

Reaction equation

HRID 1925312 reaction equation
P(Cl)(Cl)([Cl:3])=O.[I:6][C:7]1[C:16](=O)[C:15]2[C:10](=[CH:11][C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[CH:14]=2)[NH:9][CH:8]=1>CN(C=O)C>[Cl:3][C:16]1[C:15]2[C:10](=[CH:11][C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[CH:14]=2)[N:9]=[CH:8][C:7]=1[I:6]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 67521085HCID 67521085, compound

Product 1

HCID 67520363HCID 67520363, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Phosphorus oxychloride (6.743 g, 4.100 mL, 43.98 mmol) was added to a solution of 3-iodo-6,7-dimethoxyquinolin-4(1H)-one (13.237 g, 39.98 mmol) in DMF (100 mL). The mixture was stirred at 100° C. for 2 h then cooled to RT. The mixture was poured into ice water and the resulting precipitate was filtered and dried to afford 4-chloro-3-iodo-6,7-dimethoxyquinoline as a light brown solid. MS (ESI, pos. ion) m/z: 349.9 (M+H). Mass Calc'd for C11H9ClINO2: 349.

Workup

  1. temperaturethen cooled to RT
  2. filtrationthe resulting precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-38526f288540468dbb35f6741cc4944e
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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