Cesium carbonate → HCID 24823893, compound

HRID 1925328Notes

Reaction equation

HRID 1925328 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]2.[Cl:15][C:16]1[CH:21]=[C:20](Cl)[CH:19]=[CH:18][N:17]=1.C([O-])([O-])=O.[Cs+].[Cs+]>>[Cl:15][C:16]1[CH:21]=[C:20]([O:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]3)[CH:19]=[CH:18][N:17]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 335152,4-DichloropyridineHCID 54638006-Hydroxy-1-naphthoic acid

Product 1

HCID 24823893HCID 24823893, compound

Procedure

6-hydroxy-1-napthoic acid (3.2 g, 17 mmol) was reacted with 2,4-dichloropyridine (2.5 g, 17 mmol) and Cs2CO3 (16.6 g, 51 mmol) under the conditions of Example 421 step a to furnish the title compound as a brown solid. MS (ESI, pos. ion) m/z: 300.4 (M+1). Mass Calc'd for C16H10ClNO3: 299.708.

Sources & evidence

ORD record
ord-fbf7191d23734d70aa0821aed191129e
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

Loading…