HCID 86649163, compound → HCID 67520775, compound

HRID 1925514Notes

Reaction equation

HRID 1925514 reaction equation
[C:1]12([CH2:11][CH2:12][CH2:13][O:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C)=[CH:17][CH:16]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>Cl.CO>[C:1]12([CH2:11][CH2:12][CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([CH2:21][CH2:22][NH2:23])=[CH:19][CH:20]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 1

HCID 86649163HCID 86649163, compound

Product 1

HCID 67520775HCID 67520775, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

Obtained from Intermediate 50 (1.2 g, 2.94 mmol) in hydrogen chloride 1.25 M in methanol by the same procedure described in Intermediate 17. The solvent was removed under reduced pressure and the title compound was obtained as a salt (0.62 g, 67%), which was used in the next step without further purification. MS (M+): 314.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-133557197f304ed98c3047a824e850a8
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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