HRID1925953

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID97758

Pent-2-en-4-yn-1-ol

C5H6O

结构：Cc1ccc(Oc2ccc(Nc3ncnc(I)c3N)cc2C)cn1.I

HCID86615747

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(Oc2ccc(Nc3ncnc(C#C/C=C/CO)c3N)cc2C)cn1

HCID86626248

未命名化合物

收率 106.6%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1

催化剂HCID178418476

未命名化合物

溶剂HCID6342

Acetonitrile

C2H3N

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

6-Iodo-N4-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}pyrimidine-4,5-diamine hydriodide (507 mg) was dissolved in a mixed solvent of acetonitrile (19.4 mL)/triethylamine (14.5 mL), 2-penten-4-yn-1-ol (106 mg), trans-dichlorobis(triphenylphosphine)palladium(II) (38.8 mg) and copper(I) iodide (13.4 mg) were sequentially added. The title compound (373 mg) was obtained as a powder by the reaction in the same manner as in Example 9 (iv).

WORKUP

后处理

additionwere sequentially added