3-Chloro-4-(3-fluorobenzyloxy)aniline → HCID 57597277, compound

HRID 1925978Notes

Reaction equation

HRID 1925978 reaction equation
Cl[C:2]1[C:3]2[N:10]([CH2:11][CH3:12])[CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=1)[NH2:17]>CN1CCCC1=O>[Cl:13][C:14]1[CH:15]=[C:16]([NH:17][C:2]2[C:3]3[N:10]([CH2:11][CH3:12])[CH:9]=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:18]=[CH:19][C:20]=1[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=1

Participants

4

Reactant 2

HCID 70592633-Chloro-4-(3-fluorobenzyloxy)anilineHCID 714134604-Chloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine

Product 1

HCID 57597277HCID 57597277, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a solution of 4-chloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine (85 mg) in 1-methyl-2-pyrrolidone (0.94 mL) was added 3-chloro-4-[(3-fluorobenzyl)oxy]aniline (177 mg). The title compound (98 mg) was obtained as a pale-purple powder crystals by the reaction in the same manner as in Example 29.

Sources & evidence

ORD record
ord-9f223d7b534044d5832cc77e42c3e4b1
Source dataset
uspto-grants-2012_05
Patent number
US08178543B2

Reaction notes

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